The non-coding part of the genome vastly increased from worm to humans while the number of protein-coding genes remained constant. This expansion includes 3’UTRs of mRNAs with an average length of 1.2 kb in humans and functions in mRNA transport, translational control and mRNA decay. Despite the importance of 3’UTRs for spatial and temporal control of gene expression, the molecular basis of 3’UTR functions is largely unknown. We will determine complexes of 3’UTR signals
with Staufen1 protein and the ribosome which regulate mRNA stability and control translation. Using integrative structural biology approaches, including NMR spectroscopy and cryo-EM, we will unravel the molecular basis of Staufen-mediated 3’UTR functions in posttranscriptional regulation of gene expression and thus provide new insights into how deregulation can lead to diseases such as cancer and neurodegeneration.
CEITEC is a vibrant work place with excellent colleagues and infrastructure for integrative structural biology including a Titan Krios and F20 as well as six high-field NMR instruments from 500 to 950 MHz.
In addition, the historic city of Brno offers a lively atmosphere with many cultural, culinary and sportive possibilities.
We are looking for highly motivated researchers with a strong background or interest in structural biology who share our fascination for RNA/protein structure and function. Candidates should have experience in molecular biology, RNA/protein biochemistry and biophysics. Good communication and interpersonal skills and fluency in spoken and written English are required.
Salary that will be based on the candidate`s qualifications and experience.
Please send application (including CV, short statement of research background/ interests and the contact information of at least three references) by email to: firstname.lastname@example.org
Start date: upon agreement
Opened Until: 31.8.2019