Overview

A chemist position in Targeted Research Group HBV Cure (head Gabriel Birkuš, Ph.D.) is available for a highly motivated and creative scientist with expertise in organic chemistry. The project is focused on the identification of novel cGAS inhibitors.

GMP-AMP synthase (cGAS) serves as a sensor of cytosolic dsDNA and plays an essential role in innate immunity against viral/bacterial infection and cellular damage. Upon binding of dsDNA, cGAS synthesizes a cyclic dinucleotide 2’3’cGAMP that serves as a second messenger and initiates an inflammatory cellular response. An uncontrolled activation of the cGAS pathway has been implicated in autoimmune and autoinflammatory disease such as Aicardi-Goutieres syndrome or Systemic Lupus Erythematosus. Thus, inhibition of cGAS may be of therapeutic benefit in some diseases.

The successful candidate will be a member of a multidisciplinary team and be involved in our efforts to identify novel cGAS inhibitors. He or she will be responsible for the synthesis of target compounds. The candidate will also have a unique opportunity to experience lead optimization process of a drug development. An attractive salary and an opportunity to work with clinical candidates guaranteed.

Requirements
Applicant must have M.Sc. degree in organic chemistry. We are looking for independent applicants with basic knowledge of synthetic organic chemistry and standard purification techniques. Good oral and written communication skills in English are required. Position is for 36 months starting from now with possible extension.

Please submit your resume, motivation letter and contact information by e-mail to: ondrej.pav@uochb.cas.cz

Contact
Ondřej Páv, Ph.D.
Ústav organické chemie a biochemie AV ČR / Institute of Organic Chemistry and Biochemistry of the CAS
Flemingovo nám. 542/2, 166 10 Praha 6, Czech Republic